News Type: Research
Rapid progress in virtual heart modeling shows great promise for improved outcomes
Natalia A. Trayanova, Johns Hopkins Department of Biomedical Engineering Murray B. Sachs Professor and faculty in the Institute for Computational...
The Yin and Yang of calmodulin revealed by a biological signal generator
Researchers in the Calcium Signals Laboratory have discovered a mechanism that governs a cellular dialog between the two forms of calmodulin. This enables new strategies for treating diseases relating to maladaptive bioelectrical and Ca
Johns Hopkins researchers discover that an FDA-approved HIV drug may be useful in treating breast cancer metastasis
Use of drugs previously approved for other diseases, such as HIV and rheumatoid arthritis, opens attractive possibilities for treating cancer patients; as repurposed or repositioned drugs promises significant savings in development time and resources.
Error memories enable improved performance and faster learning
A study reveals that the brain controls how much it is willing to learn from the current error based on a previously unknown form of memory: a memory of errors.
Zooming in and out of the mouse brain
Researcher of the mouse auditory cortex could ultimately lead to better ways of treating people with hearing loss.
Database of Pediatric MR Images Aids Diagnosis, Treatment
By building a “cloud database” of MR images collected from children with normal and abnormal brains, researchers aim to give physicians access to a Google-like search system that will improve the way pediatric brain disorders are diagnosed and treated.
All in the family — sodium and calcium ion channels share common roots
Novel treatment strategies for arrhythmias, myotonias, and neurodegeneration provided by an ancient feedback module commonly shared between voltage-gated sodium and calcium channels.
Improving cardiac ablation treatment with virtual heart mapping
Dr. Trayanova and team are exploring whether the patient’s virtual heart could be used to noninvasively determine the optimal ablation targets with a lot more accurately.
I-STAR Lab refines ultra-low dose CT scans
Armed with pragmatism and advanced computer modeling techniques, BME researchers have made strides in improving CT image quality while reducing X-ray exposure and other negative consequences of the scanning technique.
Solving the paradox: How one bad apple spoils the pie of cardiac rhythms
BME and neuroscience researchers exploit live-cell biochemistry, electrophysiology, and mathematical simulations to solve how calmodulinopathies can lead to life-threatening cardiac arrhythmogenic events.
Engineering safer surgery: The LevelCheck algorithm translated to first clinical studies
Advanced 3D-2D image registration leverages high-speed computing to provide surgeons with an on-demand, labeled visual depiction of the spine and surgical target in the operating room.
Johns Hopkins researchers establish a digital search system for pediatric brain MRI data
A searchable digital brain image data library will provide doctors the ability to access thousands of pediatric scans. Finding similar scans to those of their own patient's will enhance diagnosis and treatment of their young patients with brain disorders.
Eye movements as a predictor of behavior
Dr. Reza Shadmehr and his team explore the relationship between eye movements and decision making.
Going native — biomedical engineers take biochemistry from the test tube into living cells
Advances made by Dr. Yue’s team reveal how calcium ion channels are properly controlled in the brain, and furnish a powerful new strategy for probing similarly large and complex molecules in the body.
Rene Vidal directs the Vision, Dynamics and Learning Lab to analyze and interpret vast amounts of data
René Vidal combines biomedical imaging, computer vision, and machine learning to develop systems that will analyze vast amounts of data and unlock previously hidden information.
BME researchers testing promising drug therapy delivery method for improved treatment of central vision loss
Time-release coating allows drug for macular degeneration to last longer, decreasing need of unpleasant treatment
BME researchers employ a biophysically-detailed heart model to test optogenentic approaches on cardiac behavior
Cardiac modeling is a key component to testing optogenetics technology, providing an accurate platform for assessing the feasibility of potential optical control strategies.
Yue Lab uncovers long-sought calcium channel interfaces targetable for therapy of cardiac and neurodegenerative diseases
JHU BME faculty member Dr. David T. Yue and members of the Calcium Signals Laboratory publish a study in Nature Communications that uncovers the molecular mechanism of Ca; regulation of Calcium channels.
TTEC clinical study proves successful in cartilage repair
A recent TTEC clinical study shows that patients who received a hydrogel scaffolding implant after the surgical repair of damaged cartilage experienced reduced pain and greater tissue growth.
Nanoscale scaffolds and stem cells show promise in cartilage repair
Jennifer Elisseeff, Professor of Ophthalmology and Biomedical Engineering and the director of the Translational Tissue Engineering Center, has been working...
Li Lab biophotonics imaging technology published in PNAS
BME Professor Xingde Li, his group members YY Zhang, K Murari, JF Xi, and other collaborators at University of Texas...
Levchenko group nabs Science Signalling cover
A paper by Andre Levchenko, Professor of Biomedical Engineering, and collaborators was featured on the cover of the Feb 28...
Information theory helps predict biological signaling
Andre Levchenko, associate professor of BME, and his lab have described techniques that enable use of information theory in analysis...
BME researchers develop novel approach to defibrillation
Three research labs at Hopkins—the Tung and Trayanova labs in Biomedical Engineering and the Berger lab in Cardiology—have combined forces...
Research from Trayanova lab published in Science Translational Medicine
Trayanova Lab has been collaborating with the laboratory of Dr. Colleen Clancy at UC Davis, Department of Pharmacology, as well...
Karchin paper highlighted in editorial
Rachel Karchin and colleagues have created a computer program to help predict which changes in the DNA code may cause pancreatic cells to become cancerous.
Levchenko paper highlighted in Nature Nanotechnology
Nature Nanotechnology not only published Andre Levchenko’s paper, “Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires,” but also gave...
Yue lab calcium signaling study published in Nature
BME faculty member David Yue and colleagues Xiaodong Liu, Phil Yang, and Wanjun Yang, all of the Calcium Signals Laboratory,...
Heart cells display ‘nano sense’ on new lab chip
Johns Hopkins Department of Biomedical Engineering faculty Andre Levchenko and Les Tung along with colleagues in Korea have found that...