News Type: Research

Researchers in the Center for Imaging Science have taken an early step towards mapping how all animal brains work.

A team of Johns Hopkins computational scientists and cancer experts devised its own bioinformatics software to evaluate how well current strategies identify cancer-promoting mutations and distinguish them from benign mutations in cancer cells.

Most people know immune cells as the first responders to trauma—killing bacteria, fungi, viruses and other invaders—but there is a hidden side, as well. Immune cells also repair the body. They are both killers and healers.

A novel peptide and drug delivery system developed by a trio of Johns Hopkins researchers is closer to improving vision care for millions of people who suffer from degenerative retinal diseases.

Dr. Wojciech Zbijewski's research is breaking new ground in imaging technology and advancing the clinical understanding of conditions affecting the bones and joints.

Meld the best of immunology and the best of engineering and what do you have? The nascent field of immunoengineering.

In a research effort that merged genetics, physics and information theory, a team at the schools of medicine and engineering...

Working as part of an international research consortium, a multidisciplinary team at the Johns Hopkins University has completed the design phase for a fully synthetic yeast genome.

Winston Timp, an assistant professor of biomedical engineering, supervised research on new computational software that determines if a human DNA sample includes an epigenetic add-on linked to cancer and other health conditions.

Johns Hopkins researchers report that a new peptide holds promise for improving treatment for degenerative retinal diseases, such as age-related macular degeneration, diabetic macular edema and diabetic retinopathy. These vascular diseases often result in central vision loss as blood vessels grow into tissues at the back of the eye, where such growth should not occur.

Jordan Green, associate professor of biomedical engineering, and his colleagues have figured out a noninvasive way to release and deliver concentrated amounts of a drug to the brain of rats in a temporary, localized manner using ultrasound.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. Those advantages, the researchers say, let such cancer cells thrive in organs like the liver and lungs, which receive a sugar-rich blood supply.

Michael Miller, the Herschel and Ruth Sedar Professor of Biomedical Engineering and University Gilman Scholar, is analyzing MRI brain images of the elderly to unveil lurking signs of Alzheimer that cognitive tests cannot detect.

Jeffrey Siewerdsen, professor of biomedical engineering, and a team of researchers have designed a new type of CT scanner that has recently been approved for commercial use by the U.S. Food and Drug Administration.

Jordan Green, associate professor of biomedical engineering, and Jonathan Schneck, professor of pathology, both at the School of Medicine, have learned that by combining a biomimetic particle along with a more traditional immunotherapy they could lengthen the lives of mice with skin cancer better than either treatment alone. Both approaches focus on activating the rodent immune system killer T cells; white blood cells that fight infection and other invaders.

In their search for new ways to treat cancer, many scientists are using a high-tech process called genome sequencing to hunt for genetic mutations that encourage tumor cells to thrive. To aid in this search, some researchers have developed new bioinformatics methods that each claim to help pinpoint the cancer-friendly mutants.

Recent PhD graduate from Johns Hopkins Biomedical Engineering, Jennifer Xu, reached an important milestone in translating her research from the laboratory to first clinical studies of a new point-of-care cone-beam CT (CBCT) scanner.

New computer models that track the motions of blood flow in the heart may reduce the risk of stroke, according to researchers at Johns Hopkins Medicine.

Using high-tech human heart models and mouse experiments, scientists at Johns Hopkins and Germany's University of Bonn have shown that beams of light could replace electric shocks in patients reeling from a deadly heart rhythm disorder.

The human brain is the most complex machine in existence. Every brain is loaded with some 100 billion nerve cells, each connecting to thousands of others, giving around 100 trillion connections. Mapping those connections, or synapses, could enable scientists to decipher what causes neurological disease and mental illness. It's an immense, daunting task.

From a napkin sketch to clinical trials, this weight-bearing CT scan wins industry accolades and provides doctors with a way to see bone breaks that may have gone undetected.

The Human Genome Project, a 13-year effort to map the complex DNA sequences that are the building blocks of our bodies and biological systems, was a landmark in genetic understanding. Critical as it was, the project only described the sequences, not the way DNA behaves and interacts with other elements to develop organisms.

When researchers try to uncover the cause of disease, they commonly start with two questions: did a quirk in the patient's genes open the door to illness, or did exposure to environmental factors play havoc with the patient's health?

Johns Hopkins Biomedical Engineering researchers have built strategic partnerships with leading BME clinicians and programs worldwide, and the department's global reach is expected to grow.

More detailed and precise MRI requires lengthier scans — taxing the patient’s ability to remain still. Daniel Herzka and his colleagues are creating solutions that compensate for motion, and deliver clearer medical images more efficiently.

Feinberg is part of a team of NASA experts selected to study how a year in space effects astronaut Scott Kelly's biology, when compared to his twin earth-bound brother, Mark, as the control.

Kevin Yarema's research group uses metabolic glycoengineering in their pancreatic and brain cancer studies, manipulating how cells process and display sugars, and looking for molecular targets to block so they can't drive cancer development.

At the nexus of research and technology, Dr Kuo secures hi-tech hardware for scientists, aids researchers determine what equipment can help them achieve research needs, and advises BME students with equipment design strategies.

A recently published study led by BME professor Xiaoqin Wang, reveals that, much like humans, marmoset monkeys distinguish between high and low notes.

The emerging field of computational medicine gives researchers a versatile and robust platform for testing the effectiveness of new cancer drug therapies, and the ability to efficiently investigate a wide range of drug interactions.