Natalia A. Trayanova, Professor of Biomedical Engineering and the Institute for Computational Medicine, and Director of the Computational Cardiac Electrophysiology Laboratory at the Johns Hopkins University, is a keynote speaker at the Challenges in Computing meeting in Oslo, Norway, Dec 14-15, 2011. The meeting marks the occasion of 10 years of operation of Simula Research Laboratory, Norway, and focuses on addressing the challenges facing real-life computational applications.