Publications

For a full overview visit:

Advanced Materials, June 2024
Nature Materials, August 2019
Nature Materials, June 2017
Nature Medicine, March 2016
Nature Materials, June 2015

Selected Publications

(*: co-first; #: co-corresponding)

  1. Schuster CR, Reiche E, Keller PR, Hu S, Soares V, Rahmayanti S, Suresh V, Harris T, Doloff JC, Tuffaha S, and Coon D. 2024. Testosterone promotes nerve tethering and acellular biomaterial perineural fibrosis in a rat wound repair model. Advances in Wound Care. doi: 10.1089/wound.2024.0043.
  2. Reiche E, Keller PR, Soares V, Schuster CR, Rahmayanti S, Mroueh J, Mroueh V, Billaud M, Hu S, Hoover-Watson H, Lian CG, Tan Y, Doloff JC, Newell-Fugate A, and Coon D. 2024. Androgenic Steroids Induce Pathologic Scarring in a Preclinical Swine Model Via Dysfunctional Extracellular Matrix Deposition. FASEB. March 26. doi: 10.1096/fj.202302144RRR.
  3. Livingston NK, Hickey JW, Sim H, Salathe SF, Choy J, Silver A, Kong J, Stelzel J, Omotoso MO, Li S, Chaisawangwong W, Roy S, Bieler J, Est Witte S, Leonard E, Ariail EC, Doloff JC, Spangler J, Mao HQ, and Schneck JP. 2024. In Vivo Stimulation of Therapeutic Antigen-Specific T Cells in an Artificial Lymph Node Matrix. Advanced Materials. Feb 15. doi: 10.1002/adma.202310043.
  4. Quiroz VM*, Wang Y*, Rakoski AI, Kasinathan D, Neshat SY, Hollister-Lock J, and Doloff JC. 2024. Hydrogel alginate considerations for improved 3D Matrix stability and cell graft viability and function in studying Type 1 Diabetes in vitro. Advanced Biology. 2024 Jan 20:e2300502. doi: 10.1002/adbi.202300502.
  5. Zhu Y, Ma J, Shen R, Lin J, Li S, Lu X, Stelzel J, Kong J, Cheng L, Vuong I, Yao Z-C, Wei C, Korinetz N, Toh WH, Choy J, Reynolds R, Shears M, Cho WJ, Livingston N, Howard G, Hu Y, Tzeng SY, Zack D, Green JJ, Zheng L, Doloff JC, Schneck J, Reddy S, Murphy S, Mao H-Q. 2023. Screening for Lipid Nanoparticles that modulate the Immune Activity of helper T cells towards enhanced Antitumour activity. Nature Biomedical Engineering. 2023 Dec 11; doi: 10.1038/s41551-023-01131-0.
  6. Doloff JC#, Ma M, Sadraei A, Tam HH, Farah S, Hollister-Lock J, Vegas AJ, Veiseh O, Quiroz VM, Rakoski A, Aresta-DaSilva S, Bader AR, Griffin M, Weir GC, Brehm MA, Shultz LD, Langer R, Greiner DL#, Anderson DG#. 2023. Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response. Science Advances. Jun 16;9(24). doi: 10.1126/sciadv.ade9488.
  7. Neshat SY, Chan CHR, Harris J, Zmily OM, Est-Witte S, Karlsson J, Shannon SR, Jain M, Doloff JC, Green JJ, Tzeng SY. 2023. Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors. Biomaterials. 2023 Sep;300. doi: 10.1016/j.biomaterials.2023.122185.
  8. Neshat SY, Bauer SJ, Rhodes KR, Quiroz VM, Wong VW, Lowmaster SM, Tzeng SY, Green JJ#, Doloff JC#. 2023. Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles. ACS Biomater Sci Eng. Jun 12;9(6):3522-3534. doi: 10.1021/acsbiomaterials.3c00329.
  9. Herrera-Mora G, Solis-Chaves P, Hernandez-Aviles G, Graham EM, Clausen-Oreamuno C, Castro-Cespedes JA, Haupt J, Jamiel M, Veiseh O, Sforza M, Hancock J, Kinney B, De Mezerville R, Langer R#, Doloff JC#, Chacon-Quiros M#. 2023. Ultrasonographic Identification of Shell Surface Types in Commercially Available Silicone Gel-Filled Breast Implants. Plast Reconstr Surg. May 24. doi: 10.1097/PRS.0000000000010758.
  10. Wilson DR, Tzeng SY, Rui Y, Neshat SY, Conge MJ, Luly KM, Wang E, Firestone JL, McAuliffe J, Maruggi G, Jalah R, Johnson R, Doloff JC, Green JJ. 2023. Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses. Feb 16. doi: 10.1002/adtp.202200219.
  11. Holzer P, Chang EJ, Rogers K, Tarlton J, Lu D, Gillespie N, Adkins J, Metea M, LaRochelle A, Wicks J, Onel B, Gullans S, Doloff JC, Scobie L, Cetrulo CL Jr, Monroy R. 2023. Large-gap peripheral nerve repair using xenogeneic transplants in rhesus macaques. Xenotransplantation. Mar;30(2). doi: 10.1111/xen.12792.
  12. Abramson HG, Curry EJ, Mess G, Thombre R, Kempski-Leadingham KM, Mistry S, Somanathan S, Roy L, Abu-Bonsrah N, Coles G, Doloff JC, Brem H, Theodore N, Huang J, Manbachi A. 2022. Automatic detection of foreign body objects in neurosurgery using a deep learning approach on intraoperative ultrasound images: From animal models to first in-human testing. Front Surg. Nov 30;9. doi: 10.3389/fsurg.2022.1040066.
  13. Weber-Levine C, Hersh AM, Jiang K, Routkevitch D, Tsehay Y, Perdomo-Pantoja A, Judy BF, Kerensky M, Liu A, Adams M, Izzi J, Doloff JC, Manbachi A, Theodore N. 2022. Porcine Model of Spinal Cord Injury: A Systematic Review. Neurotrauma Rep. Sep 1;3(1):352-368. doi: 10.1089/neur.2022.0038.
  14. Bauer SJ and Doloff JC. 2021. Less Fibrosis around silicone implants. Nature Biomed Eng. Dec;(20):1407-1408. doi: 10.1038/s41551-021-00830-w.
  15. Lai V, Neshat SY, Rakoski A, Pitingolo J, Sabedra J, Li S, Shodhan A, and Doloff JC. 2021. Crystallization of the Multi-Receptor Tyrosine Kinase Inhibitor Sorafenib for Controlled Long-Term Drug Delivery Following a Single Injection. CMBE (Young Innovators). Oct 18;14(5):471-486. doi: 10.1007/s12195-021-00708-6.
  16. Lai V, Neshat SY, Rakoski A, Pitingolo J, and Doloff JC. 2021. Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity. Adv Drug Deliv Rev. Dec;(179):113920. doi: 10.1016/j.addr.2021.113920.
  17. Neshat SY, Quiroz VM, Wang Y, Tamayo S, Doloff JC. 2021. Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions. Int J Mol Sci. Jun 24;22(13). doi: 10.3390/ijms22136777.
  18. Doloff JC*#, Veiseh O*#, de Mezerville R#, Sforza M, Perry TA, Haupt J, Jamiel M, Chambers C, Nash A, Aghlara-Fotovat S, Stelzel JL, Bauer SJ, Neshat SY, Hancock J, Romero NA, Hidalgo YE, Leiva IM, Munhoz AM, Bayat A, Kinney BM, Hodges HC, Miranda RN, Clemens MW, & Langer R#. 2021. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans. Nature Biomed Eng. June 21; doc: 10.1038/s41551-021-00739-4.
  19. Stelzel J and Doloff JC. 2021. MAP-ing a way towards tissue repair. Nature Materials. Mar 26;(20):452–453. doi: 10.1038/s41563-021-00963-y.
  20. Mao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Lin J, Doloff JC, Langer RS, and Anderson DG. 2019. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nature Biotechnology. Sep 30. doi: 10.1038/s41587-019-0247-3.
  21. Farah S*, Doloff JC*, Mueller P, Sadraei A, Han HJ, Olafson K, Tyas K, Tam HH, Hollister-Locke J, Kowalski PS, Griffin M, Meng A, McAvoy M, Graham AC, McGarrigle J, Greiner DL, Weir G, Oberholzer J, Langer R, and Anderson DG. 2019. Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations. Nature Materials. Aug;18(8):892-904. doi: 10.1038/s41563-019-0377-5.
  22. Spanoudaki V, Doloff JC, Huang W, Norcross SR, Farah S, Langer R, and Anderson DG. 2019. Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning. PNAS. Feb 26. doi: 10.1073/pnas.1815909116.
  23. Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh C, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AM, Lacik I, Langer R, Anderson DG, and Oberholzer J. 2018. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomed Eng. Aug 13. doi: 10.1038/s41551-018-0275-1.
  24. Xie X*, Doloff JC*, Yesilyurt V*, Sadraei A*, McGarrigle J, Omami M, Veiseh O, Isa D, Ghani S, Joshi I, Li J, Wang W, Tam HH, Tao J, Chen H, Yang B, Oberholzer J, Langer RS, Anderson DG. 2018. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer. Nature Biomed Eng. July 30. doi: 10.1038/s41551-018-0273-3.
  25. Khan OF, Kowalski P*, Doloff JC*, Tsosie JK, Bakthavatchalu V, Bodi CW, Haupt J, Jamiel M, Langer R, and Anderson DG. 2018. Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles. Science Advances. Jun 27;4(6):eaar8409. doi: 10.1126/sciadv.aar8409.
  26. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, and Anderson DG. 2017. Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nature Materials. Mar 20. doi: 10.1038/nmat4866.
  27. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader A, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholokia N, Thakrar R, Vietti T, Cohen J, Siniakowicz K, Qi M, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer RS, and Anderson DG. 2016. Combinatorial development of hydrogels that mitigate the foreign body response in primates. Nature Biotech. Mar;34(3):345-52. doi:10.1038/nbt.3462.
  28. Vegas AJ, Veiseh O, Gurtler M, Millman J, Paglicua F, Bader A, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, Greiner DL, Weir GC, Melton DA, Langer R, and Anderson DG. 2016. Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice. Nature Medicine. Mar;22(3):306-11. doi:10.1038/nm.4030.
  29. Veiseh O*, Doloff JC*, Ma M*, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Locke J, Aresta-Dasilva S, Bochenek M, Mendoza-Elisa J, Wang Y, Qi M, Lavin D, Chen M, Dholokia N, Thakrar R, Lacik I, Weir GC, Oberholzer J, Greiner DL, Langer R, and Anderson DG. 2015. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nature Materials, Jun; 14(6):643-51.
  30. Doloff JC*, Chen CS*, and Waxman DJ. 2014. Anti-tumor innate immunity activated by metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2. Molecular Cancer, Jun 26; 13(1): 158.
  31. Chen CS*, Doloff JC*, and Waxman DJ. 2014. Intermittent metronomic drug schedule is essential for activating anti-tumor innate immunity and tumor xenograft regression.  Neoplasia, Jan; 16(1): 84-96.
  32. Doloff JC and Waxman DJ. 2012. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression, Cancer Research, Mar 1; 72(5): 1103-15.